BACKGROUND: Chronic antipsychotic drug treatment may cause tardive dyskinesia (TD), a long-term movement disorder. Gamma-aminobutyric acid (GABA) agonist drugs, which have intense sedative properties and may exacerbate psychotic symptoms, have been used to treat TD. OBJECTIVES: To determine the effects of GABA agonist drugs (baclofen, gamma-vinyl-GABA, gamma-acetylenic-GABA, progabide, muscimol, sodium valproate and tetrahydroisoxazolopyridine (THIP)) for people with antipsychotic-induced tardive dyskinesia (TD) and schizophrenia or other chronic mental illnesses. SEARCH STRATEGY: We updated the previous Cochrane review by searching the Cochrane Schizophrenia Group Register (September 2003). We searched references for further trial citations and, where possible, contacted authors. SELECTION CRITERIA: Randomised controlled trials comparing use of non-benzodiazepine GABA agonist drugs with placebo or no intervention, involving people with schizophrenia or other chronic mental illnesses with signs of antipsychotic-induced TD. DATA COLLECTION AND ANALYSIS: Working independently, we selected and critically appraised studies, extracted data and analysed on an intention-to-treat basis. Where possible and appropriate we calculated risk ratios (RR) and their 95% confidence intervals (CI) with the number needed to treat (NNT). For continuous data Weighted Mean Differences (WMD) were calculated. MAIN RESULTS: We identified eight small poorly reported studies for inclusion. For the outcome of ‘no clinically important improvement in tardive dyskinesia’ GABA agonist drugs were not clearly better than placebo (n = 108, RR 0. Deterioration in mental state was more likely to occur in people receiving GABA medication (n = 95, RR 2. A greater proportion of people allocated GABA medication may fail to complete the trial compared with those allocated placebo (20% versus 9%), but this difference was not statistically significant (n = 136, RR 1. There is a suggestion of an increase in ataxia (loss of power of muscular coordination) for both baclofen and sodium valproate (n = 95, RR 3. Withdrawal of tetrahydroisoxazolopyridine (THIP) may cause seizures. REVIEWERS’ CONCLUSIONS: Evidence of the effects of baclofen, progabide, sodium valproate, or THIP for people with antipsychotic-induced TD is inconclusive and unconvincing. Any possible benefits are likely to be outweighed by the adverse effects associated with their use. PMID: 15494993 [PubMed – in process] Thread: Side effects from Prohormones. Show Printable Version Email this Page’ Subscribe to this Thread’ Search Thread. Side effects from Prohormones, anabolic 250. You’ve read alot of feedback regarding ph’s but would like to see posts(feedback)about side effects? Where did we lose you? Search, seek, search, explore, search, venture, search, find. The problem, here guys, is I want one thread to compile a list of problems concerning the use of pro hormones. The problems include: 1.
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