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While not yet known whether SARMs can directly lead to cancer formation in humans, at least one SARM (Cardarine) was terminated from development by the pharmaceutical company GlaxoSmithKline because of severe toxicities including the development of multiple types of cancers in mice was established during long term studies. SARMs are thought to pose a high risk to the liver due to toxicity. An FDA notice in 2017 listed liver damage as one of its primary concerns about the use of SARMs in bodybuilding products. There is still a lot of debate among enthusiasts about whether SARMs are liver toxic, since the make up of their chemical structure theoretically suggests they are not, but the FDA warning and other evidence suggests that liver damage is indeed a risk of SARMs use, even if not as prominent as that which comes with some oral anabolic steroids which can be severely toxic to the liver. 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